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  #1 (permalink)   Spam Kill
Old 06-23-2009, 11:56 PM
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  #2 (permalink)   Spam Kill
Old 06-24-2009, 10:36 AM
bjzyxty bjzyxty is offline
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乳腺癌 病因及高危因素 已知有许多因素会诱发此病,主要有下列因素: 年龄:在女性中,发病率随着年龄的增长而上升,在月经初潮前罕见, 20 岁前亦少见,但 20 岁以后发病率迅速上升, 45 ~ 50 岁较高,但呈相对的平坦,绝经后发病率继续上升,到 70 岁左右达最高峰。死亡率也随年龄而上升,在25岁以后死亡率逐步上升,直到老年时始终保持上升 趋势。 遗传因素 家族的妇女有第一级直亲家族的乳腺癌史者,其乳腺癌的危险性是正常人群的 2~3倍。 其他乳房疾病 月经初潮年龄:初潮年龄早于 13 岁者发病的危险性为年龄大于 17 岁者的 2.2 倍 绝经年龄:绝经年龄大于 55 岁者比小于 45 岁的危险性增加 第一次怀孕年龄:危险性随着初产年龄的推迟而逐渐增高,初产年龄在 35 岁以后者的危险性高于无生育史者。 绝经后补充雌激素:在更年期长期服用雌激素可能增加乳腺癌的危险性。 口服避孕药 出生地 食物:尤其是脂肪饮食,可以增加乳腺癌的危险性。 饮酒 体重增加可能是绝经期后妇女发生乳腺癌的重要危险因素 临床表现及扩散乳腺癌 临床表现 ( 1 )无痛性肿块:乳房的无痛性肿块常是促使患者就诊的主要症状。 ( 2 )乳头溢液:溢液可以是无色、乳白色、淡黄色、棕色、血性等;可以呈水样、血样、浆液性或脓性;溢液量可多 可少,间隔时间也不一致。 ( 3 )乳头和乳晕异常:乳头扁平、回缩、凹陷,直至完全缩入乳晕下,看不见乳头。有时整个乳房抬高,两侧乳头不 在同一水平面上。乳头糜烂也是 Paget 病的典型症状。 炎性乳腺癌时局部皮肤呈炎症样表现;颜色由淡红到深红,开始时比较局限,不久即扩大到大部分乳腺皮肤,同时 伴有皮肤水肿。皮肤增厚、粗糙、表面温度升高。 乳腺癌扩散及发展 乳腺癌细胞的倍增时间平均为 90d ,在临床能发现肿块前,肿瘤的隐匿阶段平均为 12 年(6~20年)。肿瘤一旦发生,其发展可通过以下方式:局部扩展、淋巴道播散、血道播散。 乳腺癌如不经治疗,或者给药无效,会逐渐侵犯以下一些区域:淋巴腺、骨、肺、肝、脑、胸膜腔、心包渗液、高 血钙、脊髓受压 。 乳腺癌 临床表现及扩散临床表现 ( 1 )无痛性肿块:乳房的无痛性肿块常是促使患者就诊的主要症状。 ( 2 )乳头溢液:溢液可以是无色、乳白色、淡黄色、棕色、血性等;可以呈水样、血样、浆液性或脓性;溢液量可多 可少,间隔时间也不一致。 ( 3 )乳头和乳晕异常:乳头扁平、回缩、凹陷,直至完全缩入乳晕下,看不见乳头。有时整个乳房抬高,两侧乳头不 在同一水平面上。乳头糜烂也是Paget 病的典型症状。 炎性乳腺癌时局部皮肤呈炎症样表现;颜色由淡红到深红,开始时比较局限,不久即扩大到大部分乳腺皮肤,同时 伴有皮肤水肿。皮肤增厚、粗糙、表面温度升高。 乳腺癌分期国际抗癌联盟提出的 TNM 分期法( 1988 )已被广泛应用于各种肿瘤中。 TNM 国际分期法: 1 )原发肿瘤( T )分期: Tx 原发肿瘤情况不详(已被切除)。 T0 原发肿瘤未扪及。 Tis 原位癌(包括小叶原位癌及导管内癌),Paget 病局限于乳头,乳房内未扪及块物。 T1 肿瘤最大径小于 2Cm 。 T 1a 肿瘤最大径在 0.5cm 以下。 T1b 肿瘤最大径 0.5 ~ 1cm 。 T 1c 肿瘤最大径 1 ~ 2cm 。 T2 肿瘤最大径 2 ~ 5crn 。 T3 肿瘤最大径超过 5cm 。 T4 肿瘤任何大小,直接侵犯胸壁和皮肤。 T 4a 肿瘤直接侵犯胸壁。 T4b 乳房表面皮肤水肿(包括橘皮样水肿),皮肤溃疡或肿瘤周围皮肤有卫星结节,但不超过同侧乳房。 T 4c 包括 T 4a 及 T4b 。 T4d 炎性乳腺癌。 2 )区域淋巴结( N )分期: N0 区域淋巴结未扪及。 Nx 区域淋巴结情况不详(以往已切除)。 N1 同侧腋淋巴结有肿大,可以活动。 N2 同侧腋淋巴结肿大,互相融合,或与其他组织粘连。 N3 同侧内乳淋巴结有转移。 3 )远处转移( M )分期:
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  #3 (permalink)   Spam Kill
Old 06-25-2009, 06:34 AM
zl381hihi246 zl381hihi246 is offline
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  #4 (permalink)   Spam Kill
Old 06-25-2009, 04:06 PM
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  #6 (permalink)   Spam Kill
Old 06-26-2009, 09:52 PM
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  #7 (permalink)   Spam Kill
Old 06-29-2009, 01:21 AM
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  #10 (permalink)   Spam Kill
Old 07-02-2009, 12:25 PM
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  #11 (permalink)   Spam Kill
Old 07-03-2009, 09:39 PM
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  #12 (permalink)   Spam Kill
Old 07-06-2009, 01:56 AM
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  #13 (permalink)   Spam Kill
Old 08-01-2009, 08:01 AM
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  #14 (permalink)   Spam Kill
Old 08-04-2009, 06:52 AM
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  #15 (permalink)   Spam Kill
Old 08-06-2009, 07:01 AM
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