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参一胶囊说明书 【名 称】 品 名：参一胶囊 汉语拼音：Shenyi jiaonang。 【性 状】本品为胶囊剂，内容物为白色粉末；味微苦。 【参一胶囊药理作用】参一胶囊由人参皂甙Rg3单一成分组成，人参皂甙Rg3是存在于传统中药人参中一种微量的四环三 萜皂甙。药效学试验证实，人参皂甙Rg3口服，对多种动物移植性实体瘤具有抑制作用。与化疗合并用药，对小 鼠H22腹腔水型肝癌有增强疗效作用，并能调节免疫功能，防止白细胞下降，脱发等。该药尚可抑制肿瘤血管内 皮细胞的增殖生长和新生血管的形成。 【参一胶囊主要成分】人参皂甙Rg3（Ginsenoside Rg3） 【参一胶囊功能与主治】培元固本，补益气血。与化疗配合用药，有助于提高原发性肺癌、肝癌的疗效，可改善肿 瘤患者的气虚症状，提高机体免疫功能。 【参一胶囊价格用法与用量】饭前空腹口服，一次2粒，一日2次。 【不良反应】1. 少数患者服药后可出现口干、口舌生疮，如果过量服用可能出现咽干、咽痛、头晕、耳鸣、鼻中血丝、胸闷、多梦 等。 2. I期临床试验中个别受试者用药期间出现肝功能异常，但尚不能确定是否与服用本品有关。 【参一胶囊禁 忌 症】1. 具有火热症或阴虚内热者忌用。 2. 有出血倾向者忌用。 【注意事项】 【规 格】200元/盒，10mg*16片/盒，10盒/疗程，优惠活动咨询电话：010-51295178人参是我国名贵的传统中草药，早在二千多年前就被用来治病强身。人参皂甙是人参的有效化学 成分，目前已从人参中分离出40余种人参皂甙单体成分[1]。其中重要成分20(R)-人参皂甙Rg3的研究仅有20余年历史，但其抗肿瘤作用却广受重视。现将其一般特点及抗癌机制 加以综述。 1. 20(R)—人参皂甙Rg3的发现及结构特点 20(R)—参一胶囊疗效Rg3是日本学者北川勋于1980年首先制备出，并确定其分子式的。随后日本、中国、韩国、德国、美国等国 家学者也不同程度地开展了对其研究。20(R)—人参皂甙Rg3是从红参(栽培人参经晒干或烘干再蒸制而成 )中微量提取的，其提取率仅为0．003％，是人参二醇类四环三萜皂甙中人参皂甙，分子式为C42H72O 13，分子量为784.30，化学名为：20(R)-达玛烷烯二醇-3-O-β-D-葡萄吡喃糖基(1-2)-β-D-葡萄吡喃糖。它可融于甲醇、乙醇，水中溶解度低，不融于乙醚、氯仿。它与20(S)-人参皂甙Rg3是同型异构体，它的降解产物是20(R)-人参皂甙Rh2[2]；尽管三者有相似之处，但功能上不尽相同，以20(R)-人参皂甙Rg3的抗肿瘤作用最为明显。 2. 20(R)-人参皂甙Rg3抗肿瘤的作用机制 2.1 抑制肿瘤细胞的增殖 国内学者富力和鲁岐应用流式细胞术研究，发现20(R)-人参皂甙Rg3可抑制肿瘤细胞的增殖，主要作用于G2期，可有效抑制肿瘤细胞有丝分裂前期蛋白质和ATP的 合成，使肿瘤细胞增殖速度减慢。韩萍等[3]认为人参皂甙Rg3有抗肿瘤生长的作用，且与其他抗肿瘤药物，如5-氟尿嘧啶、长春新碱、环磷酰胺、氨甲喋呤等合用，有明显的协同作用。 2.2 抑制肿瘤细胞浸润 Kitagawa等[4]发现人参皂甙Rg3可选择性抑制癌细胞的浸润。Shinkai等[5]通过体外抗浸润试验证明表明：人参皂甙Rg3能明显抑制小鼠腹水肝癌细胞(MMl)、B16FE7黑色素瘤 、人小细胞肺癌(OC-10)和人胰腺癌细胞(PSN-1)的单层浸润；在25umoL／L剂量下，对上述癌细胞浸润的抑制率分别为89．0％、73．7％、84 ．2％和59．1％，对油酰磷酯酸(LPA)诱导肠系膜浸润的抑制率分别为93．8％、89．0％、90. 0％和89.0％；其机理主要是通过剂量依赖性抑制LPA导致的细胞内Ca2+的上升，从而抑制了癌细胞的 单层细胞浸润。但是，结构相似的同系物人参皂甙Rb2、20(R)-Rg2、20(S)-Rg3的抗浸润作用较弱；人参皂甙Rh1-Rh2、20(R)-Rhl、-Rc、-Re均无抗浸润活性。 2.3 对肿瘤细胞的抗转移作用 Mochizuki等[6]在B16-BL6黑色素瘤和26-M3.1结肠腺癌引起肺转移的试验中，比较从红参中提取的母核相近的3种人参皂甙：20(R)-人参皂甙Rg3和20（s）-人参皂甙Rg3及人参皂甙Rb2抗肿瘤的作用。结果表明：20(R)-人参皂甙Rg3和20(s)-人参皂甙Rg3有抑制B16—BL6黑色素瘤细胞浸润基底膜、抑制肿瘤细胞与纤维粘连蛋白和层粘连蛋白的粘 附和入侵的作用，并且抑制肿瘤周围新生血管的形成，故有抑制B16-BL6黑色素瘤肺转移的作用(但不抑制肿瘤大小的变化);而人参皂甙Rb2则无此作用。在26—M3.1结 肠腺癌引起肺转移的试验中，20(R)-人参皂甙Rg3和20(S)-人参皂甙Rg3及人参皂甙Rb2均有抑制肺转移的作用；20(R)-人参皂甙Rg3和20(S)-人参皂甙Rg3口服或静脉给药均有此作用，人参皂甙Rb2只有静脉给药时才有此作用。 Iishi等[7]报告：20(R)-人参皂甙Rg3能抑制Wistar大鼠大肠腺癌的腹膜转移，5mg／kg剂量时腹膜转移率由57％下降到1 3％。 2.4 抑制胃癌诱导的血管内皮细胞增殖 王杰军等[8]研究发现：20(R)-人参皂甙Rg3虽对血管内皮细胞增殖没有直接的影响，对胃癌细胞增殖没有影响，且经Rg3作用后的胃癌细胞 条件培养液不影响对血管内皮细胞的促增殖作用，但Rg3能抑制胃癌细胞条件培养液诱导的血管内皮细胞增殖。 其机理可能是通过下调增殖期血管内皮细胞相关生长因子受体的表达，使血管内皮细胞对肿瘤细胞分泌的生长因子 的敏感性降低，从而影响血管内皮细胞的增殖。 2.5 促进肿瘤细胞的朋凋亡 细胞凋亡(Apoptosis)是指一组生化、形态特征明显的细胞死亡，其特征为细胞内出现凋亡小体，即细 胞受体内、外各种刺激后出现细胞核固缩、染色质浓聚、细胞膜皱折、最后裂解成许多有膜包裹的颗 粒----凋亡小体。富力、鲁岐在细胞增殖动力学研究中观察到20(R)-人参皂甙Rg3促进肿瘤细胞凋亡而产生凋亡峰。 2.6 提高荷瘤小鼠的免疫功能 王庭富等[9]通过研究表明：人参皂甙Rg3可明显提高小鼠碳粒廓清速率、提高荷瘤小鼠的免疫器官(脾脏、胸腺)重量、血 清溶血素含量、淋巴细胞转化能力、NK细胞活性，从而提高小鼠非特异性免疫和特异性(包括细胞免疫和体液免 疫)免疫功能。这种促进免疫功能的作用还与剂量有一定关系，以1．5—3．0mg／kg为最佳 剂量范围。 3 20(R)—人参皂甙Rg3的临床应用 不久前，国内学者富力、鲁岐通过多年的研究，改进了从红参中提取20(R)-人参皂甙Rg3的方法，首次实现了工业化生产，经过由中国中医研究院广安门医院牵头，大连医科大学附属第一 医院、南京八一医院肿瘤中心等8家符合GCP要求的大单位为中心的临床研究，现已获得国家一类新药证书，正 式药名为参—胶囊。 I期临床试验：人体耐受性试验表明参一胶囊安全范围广，所推荐的Ⅱ期临床试用剂量(0．8mg／kg／d)无任何毒副作用；人体药物代谢动力学试验结 果表明，口服吸收良好，给药15—30分钟后血液中即可检出药物吸收峰，给药1.0—1.5小时后血药浓度 达至高峰，其半衰期为(4．84土1.41)小时：在所试剂量范围内(0.8—3.2mg／kd／d)，随 剂量增大，血药最大浓度成正比增大，提示人参皂甙药物代谢动力学规律属于一级动力学吸收、消除 过程。 Ⅱ期临床试验：通过对484例属中医气虚症的癌症(包括非小细胞肺癌、乳腺癌、胃癌、肝癌等)患者Ⅱ期临床 试验，应用参一胶囊的253例带瘤患者化疗，肺癌有效率(PR十CR)为33，3％，比单纯化疗组有效率提 高20．4％，比应用其他中成药如参芪组提高16．6％：乳腺癌、胃癌、肝癌化疗时应用参一胶囊后有效率也 均较单纯化疗组提高。研究还表明： 应用参一胶囊后能明显改善化疗气虚症的证候，有增效解毒的作用，诸如改善神疲气乏、少气懒言、呼吸气短、纳 谷少馨、自汗等；能提高肿瘤患者免疫功能，使NK细胞、T细胞亚群(CD4／CD8)数量提高，并对化疗引 起的白细胞下降有保护作用；提高肿瘤患者的生存质量，Karnofsky评分上升，体重有所增加；无明显毒 副作用，无心、肝、肾功的损害，仅见2例有口干、口舌生疮。刘基巍等[10]应用参一胶囊对乳腺癌化疗患者进行免疫扶正Ⅱ期临床研究，也表明参一胶囊在乳腺癌患者化疗期间应用可以明显 改善患者的气虚症候，并可提高患者的免疫功能。 综上所述，尽管20(R)-人参皂甙Rg3研究历史较短，但其具有抑制肿瘤生长、抗肿瘤转移和浸润、增效解毒、提高机体免疫力等作用， 将可以作为肿瘤综合治疗中的一种重要方法，并对防止术后癌症复发和转移的治疗带来新的广阔前景，但其确切机 制，包括抗肿瘤淋巴道转移等作用还有待于进一步的研究。

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抗癌平丸 抗癌机理抗癌平丸是通过抑制消化系统癌细胞增殖、调节细胞免疫及体液免疫功能，促进肿瘤细胞逆转分化等环节 达到治疗目的。经大量的实验研究表明，其抗肿瘤机制可以从以下几方面阐述： 1 、诱导消化系统癌细胞发生细胞周期阻滞，抑制肿瘤细胞分裂增殖，促使其分化，阻碍肿瘤生长，可使瘤体缩小或 消失。 2 、刺激网状内皮系统增生。增强吞噬细胞活力，提高免疫系统功能。 3 、通过消化系统癌细胞内信号传导系统，选择性抑制 Na+ 、 K+ 、 ATP 酶活性，下调癌基因表达， 诱导肿瘤细胞调亡。 4 、控制原发灶的转移及转移灶的继续扩散，明显缓解临床症状，提高生存质量。 5 、保护骨髓造血功能，增加白细胞数，降低放化疗及癌性毒素对造血系统的损伤，与化疗、放疗合用有明显的减毒 增效的作用，尤其适用于无法手术、对放化疗毒副作用无法耐受的肿瘤患者。6 、改善机体代谢，保护心、肝、肾功能。 国家中药保护品种 -- 抗癌平丸，以半枝莲、香茶菜、蛇莓、蟾酥等为主的十一味中草药组成，具有清热解毒、消肿止痛的功效。其中主 药半枝莲具有清热解毒、止血定痛的作用；香茶菜富含延命草素（ Enmein ）有抗肿瘤作用，能延长小鼠接种艾氏腹水癌后的生命，并能健胃整肠，治疗消化不良；蛇莓能清热、消肿、解毒 及治癌肿；蟾酥具有破雍结、行水湿、化毒、杀虫及定痛的功效。因而抗癌平丸可用于治疗食道癌、贲门癌、胃癌 和肝癌等。经大量临床应用验证，对抑制癌细胞的转移及扩散，以及提高机体免疫功能，保护造血系 统的有效率为 86% 。并适用于放、化疗后引起严重的胃肠道反应，如恶心、呕吐及吞咽困难等。本品采用高科技制剂工艺，设计为浓 缩微丸，对年老、体弱、晚期转移癌等不适宜手术治疗或放化疗的病人尤为适用。抗癌平丸使用说明书药品名称： 抗癌平丸 汉语拼音： Kang ai ping wan 主要成份： 珍珠菜、半枝莲、白花蛇舌草、蛇莓、藤梨根、蟾酥、香茶菜、肿节风、兰香 草、石上柏。 功能主治： 清热解毒，散瘀止痛。专用于治疗胃癌、食道癌、贲门癌、直肠癌、结肠癌等消化系统肿瘤，以及控制肿瘤的血液 、淋巴转移。 用法用量： 1g/瓶，18瓶/盒，一次 1g ，一日 3 次，饭后半小时服，或遵医嘱。 生产企业： 海南龙圣堂制药有限公司价格： 1g*18瓶/盒；150元/盒，，优惠活动咨询：010-51295178抗癌平丸康复病例抗癌平丸康复病例1：胃癌淋巴转移 李飞祥 男 56岁 （复方斑蝥胶囊配合抗癌平丸） 患者于2001年3月因胃癌做了全切除手术，11月因感觉腰骨部发胀并向下肢放射性疼痛，经医院诊断为胃癌 术后淋巴转移，呈恶性淋巴瘤，即住院化疗，2002年1月患者体质下降到只剩皮包骨头，不能再接受化疗。1 月10日开始服用复方斑蝥胶囊和抗癌平丸，一周后病人就有了食欲，精神开始好转，这一奇迹的出现引起了病人 的家属和医生的注意，在医生的观察下，病人又开始服用了三个疗程复方斑蝥胶囊和抗癌平，4月20日检查发现 肿瘤全部消失，能象正常人一样活动了。 抗癌平康复病例2：王勇亮 贲门癌肝转移 男 67岁 （抗癌平丸配合珍香胶囊） 2003年2月无明显诱因下出现进食胸骨后哽腻感，而后患者病情逐步加重，只能进流质。2003年10月中 旬胃镜检查见贲门处一菜花样肿物，表面不平，质脆，易出血，胃黏膜充血水肿，可见散在大小不等颗粒状增生和 糜烂，病理活检提示贲门腺癌，B超提示肝脏多发实性占位，腹腔多发肿大淋巴结，CT示肝脏多发 转移癌。 由于虚弱，无法进行手术、放化疗，经推荐使用抗癌平丸配合西黄丸进行治疗，服用一个疗程后症状明显改善，可 吃流质食物，两个疗程后肿瘤得到有效控制，可以自由活动，经检查肿瘤明显缩小。 抗癌平康复病例3：

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This is a pair of men's Nike Air Max 90 running trainers in gray white and purple.As we all know,the Nike Air Max 90 was first released in 1990 and was known as the Air Max or the Air Max III until 2000 when Nike reissued these classic Nike running shoes. The Air Max 90 was originally produced with a Duromesh upper, synthetic suede, and synthetic leather. The striking color combinations, clearn lines made the Air Max 90 highly sought after in its original release and still extremely popular today. If you are Nike funs,then this mens trainers are your best choice.