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1、外阴白斑阴鳞状上皮增生:是以外阴瘙痒为主要症状但病因不明的外阴疾病。虽无导致此病发生的直接原因,但外阴局部皮 肤长期处于潮湿状态和阴道排出物的刺激等解剖生理因素可能与其发病有关。此病多见于绝经后女性,但亦可发生 在生育年龄。 外阴白斑外阴瘙痒是此病的主要症状,患者多难忍受。由于搔抓局部时刺激较大的神经纤维,可抑制瘙痒神经纤维反射,患 者瘙痒可暂时得到缓解,但搔抓又可导致皮肤进一步的损伤,从而触发新的瘙痒反应以致瘙痒更剧,形成恶性循环 。 外阴白斑外阴的病损范围不一,主要累及大阴唇、阴唇间沟、阴蒂包皮、阴唇后联合等处,长呈对称性。外阴白斑早期病变较轻时,皮肤颜色呈暗红色或粉红色,角化过度部位则呈白色。由于长期的搔抓和摩擦,皮肤增厚似皮革 ,色素增加,皮肤纹理明显突出,皮嵴隆起,呈多数小多角性扁平丘疹,并群集成片,出现苔癣样变,故临床上亦 称此病为慢性单纯性苔癣。由于局部潮湿、搔抓和摩擦的程度不同,以及对局部用药的反应不一,患者不同部位的 病损形态有差别,严重者可因搔抓引起表皮抓破、皲裂、溃疡。
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