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  #1 (permalink)   Spam Kill
Old 06-24-2009, 12:10 AM
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  #2 (permalink)   Spam Kill
Old 06-25-2009, 08:09 PM
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Old 06-27-2009, 05:55 AM
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Old 06-28-2009, 06:32 AM
bjzyxty bjzyxty is offline
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宫颈癌晚期致病机理人类乳头瘤病毒( HPV )感染在宫颈癌病因中具有重要作用。在浸润前或浸润期宫颈癌中存在 HPV16 、 18 、 31 和 33 型,宫颈良性扁平疣中存在 HPV6 和 11 型。美国 513 例宫颈癌患者的两年随访发现 HPV 感染消退者为 25 %,持续不变者为 60 %,加重者为 14 %。几个癌基因对宫颈癌的发生是有关的,如 c-myc 基因过度表达,远处转移的危险性估计增加了 6 倍, ras 基因表达增加与淋巴结转移有关。晚期宫颈癌常呈局部扩散和淋巴结转移,肿瘤蔓延至阴道上段、宫旁、膀胱和直肠是最常见的部位。宫颈癌早期可向外侧和后 方延伸,累及主韧带和宫骶韧带。肿瘤扩展至宫旁,一侧或双侧输尿管阻塞,导致肾盂积水和尿毒症是常见的晚期 症状。晚期病例可直接扩散至膀胱或直肠,肿瘤浸润或穿透可导致腹腔内扩散和侵犯小肠。 一旦发生淋巴血管浸润,肿瘤栓可进入宫旁、盆腔、主动脉旁淋巴结。晚期病例通过胸导管可累及左侧锁骨上淋巴 管。淋巴管阻塞可导致双侧淋巴管水肿和转移至腹股沟和外生殖器。血运扩散是直接由毛细血管或浸润或通过交通 的淋巴血管间隙引起。 ( 1 )与性生活、婚姻、妊娠的关系 性生活过早(指 18 岁前即有性生活)的妇女,其宫颈癌的发病率较 18 岁以后开始性生活的要高 4 倍。若妇女性生活开始早,有患有梅毒、淋病等性传播疾病,则其宫颈癌的发病率将较正常妇女高 6 倍。已证实若妇女与多个男子发生性关系,其发生宫颈癌的机会较多。这可能是青春期前的妇女,下生殖道尚未成 熟,对致癌因素的刺激比较敏感,若较早开始性生活,一旦被某些细菌或病毒感染后,容易引发癌症 。( 2 )宫颈癌治疗外源因素 犹太人宫颈癌发病率低,研究其原因可能与犹太人的风俗是男婴出生后需切除包皮有关。但也有认为在未切除包皮 的犹太人群中,妇女患宫颈癌者也少见。目前尚缺乏实验资料证实包皮切除能减少宫颈癌的发生,虽 然 Nahmos 曾从男子的包皮垢中分离出 HSV-2 型病毒。 Singer ( 1976 )等曾提出精子头部所含的组蛋白和精蛋白是一种致癌因素,可作用于宫颈化生细胞的 DNA 细丝。 Coppelson 及 Reid 等认为成年妇女特别在妊娠期,鳞化活跃的宫颈上皮最容易恶变,这可能与 DNA 病毒有关。当然精子本身在特殊情况下也会对宫颈起诱变作用,这些新的假设尚待进一步证实。 ( 3 )内分泌因素 性激素是否会促进宫颈癌的发生也是多年来研究的问题。动物实验用雌激素诱导小鼠发生鳞癌已获得成功,但在人 体用外源性雌激素诱发宫颈癌尚未获得确实证据。 ( 4 )性传播性疾病 60 年代以前认为梅毒患者的宫颈癌发生率高,但至今尚未找到梅毒引起宫颈癌的直接证据。滴虫性阴道 炎常与治疗宫颈癌前病变或宫颈癌并存。 Parfen 等发现宫颈不典型增生合并滴虫性阴道炎者,其转化为浸润癌的机会增加,并已成功地用滴虫感染动物,诱发出宫 颈癌。但两者都为性传播疾病,可以并存,且宫颈不典型增生患者的阴道酸碱度常偏于碱化,有利于滴虫生长,故 不能证实滴虫感染可诱发宫颈癌。
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Old 07-03-2009, 02:55 PM
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Old 07-10-2009, 09:49 PM
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